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Dr. Melina Kibbe
Implications of Sex Bias in Research
Data shows that sex bias exists in human surgical clinical research. Few studies include men and women equally, less than one-third performed data analysis by sex, and there is wide variation in inclusion and matching of the sexes among the specialties and the journals reviewed. Because clinical research serves as the foundation for evidence-based medicine, it is imperative that this disparity be addressed so that therapies benefit both sexes. This talk will highlight Dr. Kibbe’s work showing that nitric oxide was more effective in male than female rats. This talk caused a national sensation, including Dr. Kibbe being interviewed by Leslie Stahl on 60 Minutes regarding the sex bias that exists in basic and translational research. Dr. Kibbe’s work contributed to the new NIH policy that now requires investigators to outline their plans to include sex as a variable for all preclinical research.

At the conclusion of this lecture participants will be able to:
  1. Explain the sex disparity that exists in the development and evaluation of drugs, devices, and medical therapies
  2. Discuss the sex disparity that exists in biomedical and clinical research in surgery and other disciplines
  3. Present solutions that can improve sex inclusion in biomedical and clinical research